What does this research mean for the field?

Physiological shifts in endogenous plasma atrial natriuretic factor (ANF) concentrations during changes in sodium status significantly modulate the relationship between angiotensin II and aldosterone, with ANF attenuating the enhanced aldosterone response seen in sodium depletion. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1993Clinical and Experimental Hypertension

Atrial Natriuretic Factor and Changes in the Aldosterone Response to Angiotensin II in Sodium Depleted Dogs

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Why the study?

Does low-dose ANF infusion alter the angiotensin II/aldosterone relationship in sodium-depleted dogs?

Structured PICO

Does low-dose ANF infusion alter the angiotensin II/aldosterone relationship in sodium-depleted dogs?

Population

6 conscious beagle dogs

Intervention

Background constant low-dose infusion of atrial natriuretic factor (ANF) (1.5 pmol/kg/min) during incremental infusions of angiotensin II (3, 9 and 27 ng/kg/min) in a sodium deplete state

Comparator

Sodium replete and sodium deplete states without ANF infusion, receiving the same incremental infusions of angiotensin II

Outcome

Relationship between achieved arterial angiotensin II concentrations and the plasma aldosterone responsesurrogate

Physiological shifts in endogenous plasma ANF levels during changes in sodium status significantly contribute to alterations in the angiotensin II/aldosterone relationship.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open ANF modulation of angiotensin II/aldosterone dynamics in human sodium homeostasis.

Cite This Study

Richards et al. (1993) studied this question.

synapsesocial.com/papers/6a1be904ea84844e355f2a8b https://doi.org/10.3109/10641969309032941

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Atrial Natriuretic Factor and Changes in the Aldosterone Response to Angiotensin II in Sodium Depleted Dogs

Structured PICO

Discussion

Implication

Cite This Study

Atrial Natriuretic Factor and Changes in the Aldosterone Response to Angiotensin II in Sodium Depleted Dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider