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April 1, 1978Circulation ResearchOpen Access

The relationship between body fluid volume, sodium ion concentration, and sensitivity to pressor effect of angiotensin II in dogs.

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Population

16 nephrectomized dogs undergoing hemodialysis (11 for volume states, 5 for sodium states)

Comparison

Angiotensin II administration at varying doses vs Different volume states and different plasma…

Design

Preclinical

Authors

ACAllen W. CowleyPreventive CardiologyTLThomas E. LohmeierJackson Memorial Hospital

Discussion

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Implication

Short-term sodium/volume changes do not alter angiotensin II vascular sensitivity in animals; hypothesis-generating for endogenous levels driving human observations.

Structured PICO

P
Population
16 nephrectomized dogs undergoing hemodialysis (11 for volume states, 5 for sodium states)
I
Intervention
Angiotensin II administration at varying doses
C
Comparator
Different volume states (normal, contracted, expanded) and different plasma sodium concentrations (140, 146, 156 mEq/liter)
O
Outcome
Acute pressor responsiveness to Angiotensin II (A II dose-pressure response curves)surrogate

Short-term alterations in sodium or water balance do not alter true vascular sensitivity to angiotensin II, suggesting apparent changes are due to preexisting endogenous angiotensin II levels.

Cite This Study

Cowley et al. (1978) studied this question.

synapsesocial.com/papers/6a8a3e60b1e5d05ea8ec970ahttps://doi.org/10.1161/01.res.42.4.503
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Sodium Interaction in Blood Pressure Maintenance of Renal Hypertensive and Normotensive Rats1973 · 291 citations
  2. 2Influence of Sodium Intake on Vascular and Adrenal Angiotensin II Receptors1976 · 62 citations
  3. 3Angiotensin II antagonists in dehydrated rabbits without baroreceptor reflexes1977 · 10 citations
  4. 4Prior receptor occupancy as a determinant of the pressor activity of infused angiotensin II in the rat.1975 · 126 citations
  5. 5Quantification of Intermediate Steps in the Renin-Anglotensin-Vasoconstrictor Feedback Loop in the Dog1972 · 33 citations