What question did this study set out to answer?

To determine whether dietary sodium depletion alters the central cardiovascular response and receptor sensitivity to intraventricular angiotensin II infusion.

August 1, 1979AJP Heart and Circulatory Physiology

Hemodynamics of central infusion of angiotensin II in normal and sodium-depleted dogs

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Why the study?

Does sodium deprivation influence the hemodynamic response to central infusion of angiotensin II in dogs?

Population

Pentobarbital-anesthetized dogs on either normal or sodium-deficient diets

Comparison

Intraventricular administration of angiotensin… vs Normal diet versus sodium-deficient diet

Design

Preclinical

Follow-up

10 minutes after onset of infusion

Authors

KBK. Bridget BrosnihanVascular Medicine GBGianni BertiOspedale "Santa Maria delle Croci" di Ravenna CFCarlos M. FerrarioPreventive Cardiology

Discussion

Member takes

Implication

Sodium depletion does not alter central AII pressor effects in dogs; leaves open translation to human sodium-sensitive hypertension.

Key Points

To determine whether dietary sodium depletion alters the central cardiovascular response and receptor sensitivity to intraventricular angiotensin II infusion.
Administered intraventricular infusions of angiotensin II (100 ng·kg⁻¹·min⁻¹) to pentobarbital-anesthetized dogs maintained on either normal or sodium-deficient diets.
Measured mean arterial blood pressure, peripheral vascular resistance, regional cerebral blood flow via xenon-133 washout, and peripheral plasma renin activity.
Intraventricular angiotensin II elevated blood pressure by an average of 15 ± 2 mmHg in normal dogs and 17 ± 4 mmHg in sodium-depleted dogs within 10 minutes, driven by increased peripheral resistance (2.87 ± 1.20 vs. 1.67 ± 0.43 units).
Peak pressor responses induced sustained bradycardia exclusively in sodium-depleted animals, while regional cerebral blood flow and peripheral plasma renin activity remained unaltered across both groups.

Structured PICO

Does sodium deprivation influence the hemodynamic response to central infusion of angiotensin II in dogs?

Population

Pentobarbital-anesthetized dogs on either normal or sodium-deficient diets

Intervention

Intraventricular (IVT) administration of angiotensin II (AII) at 100 ng.kg-1.min-1

Comparator

Normal diet versus sodium-deficient diet

Outcome

Arterial blood pressuresurrogate

Sodium deprivation does not appear to influence the sensitivity of the central angiotensin II receptor in regulating blood pressure in dogs.

Cite This Study

Brosnihan et al. (1979) studied this question.

synapsesocial.com/papers/6a87f1dc04120b0d52eb30e0 https://doi.org/10.1152/ajpheart.1979.237.2.h139

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