Key result
Angiotensin II maintains sodium balance without large GFR or arterial pressure fluctuations during varying intake.
Why the study?
Does angiotensin II regulate arterial pressure and renal hemodynamics during chronic variations in sodium intake in dogs?
Population
Dogs undergoing chronic increases in sodium intake from 5 to 495 mmol/day
Comparison
Constant intravenous infusion of 4.85 pmol of… vs Control dogs with intact angiotensin II regulation
Design
Preclinical
Authors
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Does not support changes in human sodium or pressure management; leaves open translational relevance of angiotensin II from canine models.
Does angiotensin II regulate arterial pressure and renal hemodynamics during chronic variations in sodium intake in dogs?
Angiotensin II plays a major role in maintaining sodium balance without large fluctuations in glomerular filtration rate or arterial pressure during chronic variations in sodium intake.
Hall et al. (1980) studied this question. Angiotensin II infusion or SQ 14 225 (angiotensin II blockade) vs. Control dogs was evaluated on Arterial pressure, glomerular filtration rate, and renal sodium reabsorption. During chronic variations in sodium intake, angiotensin II plays a major role in allowing sodium balance without large fluctuations in glomerular filtration rate or arterial pressure.
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