January 1, 1992AJP Regulatory Integrative and Comparative Physiology

Pressure natriuresis and angiotensin II in reduced kidney mass, salt-induced hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does pressure natriuresis and decreased ANG II formation prevent sodium retention and hypertension during high sodium intake in dogs with reduced kidney mass?

Population

Dogs with reduced kidney mass (n=7)

Comparison

High sodium intake under various conditions vs Baseline sodium intake (36 meq/day)

Design

Preclinical

Follow-up

7 days

Authors

JHJohn E. HallCanadian Institute for Advanced Research HMH. L. MizelleOrlando Regional Medical Center MBMichael W. BrandsGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Supports pressure natriuresis role in salt-sensitive hypertension with reduced renal mass; leaves open translation to human CKD.

Structured PICO

Does pressure natriuresis and decreased ANG II formation prevent sodium retention and hypertension during high sodium intake in dogs with reduced kidney mass?

Population

Dogs with reduced kidney mass (n=7)

Intervention

High sodium intake (466 meq/day for 7 days) under various conditions (intact pressure natriuresis, servo-controlled renal perfusion pressure, constant ANG II levels, or both)

Comparator

Baseline sodium intake (36 meq/day)

Outcome

Mean arterial pressure (MAP) and cumulative sodium balancesurrogate

Pressure natriuresis and decreased ANG II formation are critical mechanisms for minimizing sodium retention and hypertension during high sodium intake in the setting of reduced kidney mass.

Cite This Study

Hall et al. (1992) studied this question.

synapsesocial.com/papers/6a82177f7db08d7cfd3f0c1a https://doi.org/10.1152/ajpregu.1992.262.1.r61

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

January 1, 1992AJP Regulatory Integrative and Comparative Physiology

Pressure natriuresis and angiotensin II in reduced kidney mass, salt-induced hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does pressure natriuresis and decreased ANG II formation prevent sodium retention and hypertension during high sodium intake in dogs with reduced kidney mass?

Population

Dogs with reduced kidney mass (n=7)

Comparison

High sodium intake under various conditions vs Baseline sodium intake (36 meq/day)

Design

Preclinical

Follow-up

7 days

Authors

JHJohn E. HallCanadian Institute for Advanced Research HMH. L. MizelleOrlando Regional Medical Center MBMichael W. BrandsGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Supports pressure natriuresis role in salt-sensitive hypertension with reduced renal mass; leaves open translation to human CKD.

Structured PICO

Does pressure natriuresis and decreased ANG II formation prevent sodium retention and hypertension during high sodium intake in dogs with reduced kidney mass?

Population

Dogs with reduced kidney mass (n=7)

Intervention

High sodium intake (466 meq/day for 7 days) under various conditions (intact pressure natriuresis, servo-controlled renal perfusion pressure, constant ANG II levels, or both)

Comparator

Baseline sodium intake (36 meq/day)

Outcome

Mean arterial pressure (MAP) and cumulative sodium balancesurrogate

Pressure natriuresis and decreased ANG II formation are critical mechanisms for minimizing sodium retention and hypertension during high sodium intake in the setting of reduced kidney mass.

Cite This Study

Hall et al. (1992) studied this question.

synapsesocial.com/papers/6a82177f7db08d7cfd3f0c1a https://doi.org/10.1152/ajpregu.1992.262.1.r61

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark