⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

October 1, 1978Circulation ResearchOpen Access

Subpressor angiotensin infusion, renal sodium handling, and salt-induced hypertension in the dog.

J W DeClue Arthur C. Guyton Allen W. Cowley T. G. Coleman Rachel Norman R E McCaa

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to understand how subpressor levels of angiotensin and sodium chloride influence blood pressure and renal sodium handling in dogs.
Studied 16 dogs over 2-8 weeks with isotonic NaCl infusion and subpressor angiotensin infusion.
Monitored arterial pressure changes in response to sodium infusion with and without angiotensin.
Assessed urinary sodium output relative to arterial pressure changes.
In dogs with sodium infusion alone, arterial pressure increased by 3 mm Hg.
With angiotensin infusion, arterial pressure rose by 39 mm Hg alongside sodium infusion.
No significant difference in urinary sodium output was observed between the two conditions, indicating angiotensin's role in sodium retention.

No abstract yet

We only have this paper's title and publication details.

Read it at the source→

Ask about this paper

Answers are grounded in this paper and cite their sources.

Ask your own question…

Implication

Does not alter hypertension management; leaves open angiotensin-sodium interactions in human disease.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

DeClue et al. (1978) studied this question.

synapsesocial.com/papers/6a70f0c22163a0a01bc52387 https://doi.org/10.1161/01.res.43.4.503

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 10 related papers. Consider them for comparative context:

1Hemodynamics and blood volume in angiotensin II salt-dependent hypertension in dogspreclinical · 1989 · 36 citations
2Effects of prolonged infusion of angiotensin II in normal dogspreclinical · 1963 · 39 citations
3Long-term Regulation of Arterial Pressure, Glomerular Filtration and Renal Sodium Reabsorption by Angiotensin II in Dogspreclinical · 1980 · 14 citations
4Hemodynamic Aspects of Prolonged Infusion of Angiotensin into Unanesthetized Dogspreclinical · 1965 · 25 citations
5An Altered Relation between Arterial Pressure and Plasma Angiotensin II Concentration Resulting from Prolonged Infusion of Angiotensin IIOriginal Research · 1978 · 3 citations
6Hypertension in dogs during antidiuretic hormone and hypotonic saline infusionOriginal Research · 1979 · 27 citations
7Limited hypertensive effect of infusion of angiotensinpreclinical · 1965 · 16 citations
8Chronic Hypertension Elicited by Infusion of Angiotensin into Vertebral Arteries of Unanaesthetized Dogspreclinical · 1971 · 37 citations
9The American College of Cardiology/American Heart Association classification of chronic hypertension in pregnancy has better clinical applicability and risk assessment than the traditional severe and mild hypertension approach – lessons from a population-based studyThe Journal of Maternal-Fetal & Neonatal Medicine · 2026
10CaMKIIδ-TRPC6 Activates an RyR-BK Ca Feedback Axis in Aging ArteriesCirculation Research · 2026

HMore on Hypertension management

More from Circulation Research

More from Coleman University

More from Wiss Janney Elstner Associates