Why the study?
Does infusion of angiotensin cause a similar degree of arterial pressure elevation as single injections or experimental renal hypertension in anesthetized dogs?
Population
Anesthetized dogs (normal and with chronic renal hypertension)
Comparison
Infusion of angiotensin vs Single injections of angiotensin; normal dogs
Design
Preclinical
Authors
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Angiotensin infusion's limited ceiling in dogs should not inform human hypertension management; leaves open compensatory mechanisms in chronic renal models.
Does infusion of angiotensin cause a similar degree of arterial pressure elevation as single injections or experimental renal hypertension in anesthetized dogs?
Angiotensin infusion produces a limited "ceiling" hypertensive response in dogs, likely due to compensatory cardiovascular reflexes and tachyphylaxis, which is higher in chronic renal hypertension.
McCubbin et al. (1965) studied this question.