Key result
Angiotensin II administration in anesthetized dogs elevated systemic and pulmonary arterial pressures and depressed heart rate, suggesting increased myocardial work and reflex bradycardia.
Why the study?
Does angiotensin administration alter pulmonary and systemic hemodynamics in anesthetized dogs?
Population
18 morphine-urethan anesthetized dogs (10 in single injection group, 8 in infusion group)
Design
Preclinical
Follow-up
30 minutes (for infusion group)
Authors
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Supports mechanistic insights into angiotensin II in hypertension; leaves open translation to conscious models or human therapy.
Does angiotensin administration alter pulmonary and systemic hemodynamics in anesthetized dogs?
Angiotensin induces systemic vasoconstriction and reflex bradycardia, leading to secondary elevations in left ventricular filling and pulmonary pressures, supporting its potential role in essential hypertension.
Chimoskey et al. (1962) studied Hemodynamics (n=10). Synthetic valine 5 angiotensin II amide was evaluated on Systemic and pulmonary arterial pressures and heart rate. Angiotensin II administration in anesthetized dogs elevated systemic and pulmonary arterial pressures and depressed heart rate, suggesting increased myocardial work and reflex bradycardia.
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