Key result
Intravenous angiotensin II (2.5-20 µg) demonstrated a strong cardioaccelerator action mediated by efferent nerves, with initial cardioinhibition dependent on sinoaortic pressoreceptor reflexes.
Population
Dogs under the influence of morphine and chloralose, including intact, mechanically buffered, and sinoaortic…
Comparison
Synthetic angiotensin II vs Baseline and comparison between intact…
Design
Preclinical
Authors
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Animal data on angiotensin II's cardiac effects warrant no practice change; leaves open translation to human autonomic regulation.
This study demonstrates that angiotensin II possesses a direct cardioaccelerator effect that is typically masked by a baroreceptor-mediated reflex bradycardia.
Nishith et al. (1962) studied Healthy dogs (animal model). Synthetic angiotensin II vs. Baseline / unbuffered / intact animals was evaluated on Heart rate and blood pressure. Intravenous angiotensin II (2.5-20 µg) demonstrated a strong cardioaccelerator action mediated by efferent nerves, with initial cardioinhibition dependent on sinoaortic pressoreceptor reflexes.
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