What question did this study set out to answer?

To investigate the biological activity of synthetic angiotensin II on tissue catecholamine content, vascular responses, and central regulation of catecholamine excretion.

November 1, 1965Acta Physiologica Scandinavica

Effects of Synthetic Angiotensin II on Catecholamine Levels and Biological Activity

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Why the study?

Does synthetic angiotensin II alter catecholamine levels and biological activity in animal models?

Population

Isolated rabbit kidneys, anesthetized rats, and dog cross-circulation preparations

Design

Preclinical

Authors

JBJoseph P. BuckleyUW Health University Hospital

Discussion

Member takes

Implication

Animal data provide no basis to alter catecholamine management; leaves open central angiotensin effects on adrenaline excretion for human studies.

Key Points

To investigate the biological activity of synthetic angiotensin II on tissue catecholamine content, vascular responses, and central regulation of catecholamine excretion.
Perfused synthetic angiotensin II into isolated rabbit kidneys to monitor changes in perfusion pressure and responsiveness to tyramine-induced vasoconstriction.
Administered synthetic angiotensin II intravenously in anesthetized rats to measure catecholamine content in heart and kidney tissues.
Infused angiotensin II into the carotid inflow of vascularly isolated recipient heads in dog cross-circulation preparations to evaluate urinary adrenaline and noradrenaline excretion.
Synthetic angiotensin II perfusion did not alter catecholamine stores in rabbit kidneys or potentiate tyramine vasoconstriction, but induced slow rhythmic perfusion pressure waves of 30 to 120 mm of water at 2 to 3 cycles per minute.
Intravenous infusion of angiotensin II produced no significant alterations in catecholamine levels within rat heart and kidney tissues.
Carotid infusion to the isolated head in cross-circulation preparations produced approximately a 50% increase in recipient urinary adrenaline excretion, while noradrenaline excretion remained unchanged.

Structured PICO

Does synthetic angiotensin II alter catecholamine levels and biological activity in animal models?

Population

Isolated rabbit kidneys, anesthetized rats, and dog cross-circulation preparations

Intervention

Synthetic angiotensin II (perfusion, infusion, or administration via carotid inflow)

Outcome

Catecholamine levels (tissue content in kidney and heart, urinary excretion of adrenaline and noradrenaline) and biological activity (vasoconstrictive effect of tyramine, perfusion pressure)surrogate

Synthetic angiotensin II increases urinary adrenaline excretion in dogs but does not alter tissue catecholamine content in rabbit kidneys or rat hearts/kidneys.

Cite This Study

Joseph P. Buckley (1965) studied this question.

synapsesocial.com/papers/6a854c7ea95ccb34714e17ad https://doi.org/10.1111/j.1748-1716.1965.tb04271.x

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Implication

Animal data provide no basis to alter catecholamine management; leaves open central angiotensin effects on adrenaline excretion for human studies.

Effects of Synthetic Angiotensin II on Catecholamine Levels and Biological Activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Synthetic Angiotensin II on Catecholamine Levels and Biological Activity

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider