Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1971Circulation Research

Effects of Angiotensin Infusion on Catecholamine Uptake and Reactivity in Blood Vessels

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does angiotensin modify catecholamine uptake and vascular reactivity in animal models?

Population

Rats and isolated perfused arteries of rabbits

Design

Preclinical

Authors

PKPhilip A. KhairallahCleveland State UniversityDDD DávilaHospital Nacional Dos de MayoNPN. PapanicolaouInserm

Discussion

Loading...

Member takes

Implication

Suggests angiotensin augments sympathetic vascular effects in animals; leaves open relevance to human hypertension or heart failure.

Structured PICO

Does angiotensin modify catecholamine uptake and vascular reactivity in animal models?

P
Population
Rats and isolated perfused arteries of rabbits
I
Intervention
Angiotensin infusion (1, 12, and 45 ng/kg/min for 5, 30, or 120 minutes) or intravenous high titer angiotensin II antibodies
O
Outcome
Uptake of metaraminol or norepinephrine in tissues, and contractile responses to norepinephrine in isolated arteriessurrogate

Angiotensin modifies the uptake and inactivation of sympathetic neurotransmitters, potentially altering physiological responses to sympathetic stimulation.

Cite This Study

Khairallah et al. (1971) studied this question.

synapsesocial.com/papers/6a8299a40f52607ca18adb57https://doi.org/10.1161/01.res.28.5.ii-96
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin Infusion on Catecholamine Uptake and Reactivity in Blood Vessels1971 · 9 citations
  2. 2Release of Adrenal Catecholamines by Angiotensin II1966 · 118 citations
  3. 3Effects of Synthetic Angiotensin II on Catecholamine Levels and Biological Activity1965 · 16 citations
  4. 4Effect of angiotensin on the response to noradrenaline and sympathetic nerve stimulation, and on 3H-noradrenaline uptake in cat mesenteric blood vessels1968 · 54 citations
  5. 5The influence of angiotensin on the uptake of noradrenaline by the isolated heart of the rabbit1970 · 30 citations