Why the study?
Does low-dose angiotensin II infusion cause renal vasoconstriction and electrolyte conservation in volume-expanded dogs?
Population
Volume-expanded dogs with acutely denervated kidneys
Design
Preclinical
Authors
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No direct clinical implications from canine data; leaves open angiotensin II's role in human renal vasoconstriction and electrolyte handling.
Does low-dose angiotensin II infusion cause renal vasoconstriction and electrolyte conservation in volume-expanded dogs?
Physiological increments in angiotensin II directly cause renal vasoconstriction and electrolyte conservation, suggesting a role in salt homeostasis.
William H. Waugh (1972) studied this question.
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