Inhibition of Renin Secretion by Angiotensin .II.

A. J. Vander; Glenn W. Geelhoed

doi:10.3181/00379727-120-30547

November 1, 1965Experimental Biology and Medicine

Inhibition of Renin Secretion by Angiotensin .II.

View at Publisher

Ask AI

Bookmark

Share

Why the study?

Does intravenous infusion of angiotensin II inhibit renin secretion in dogs?

Key Points

To determine whether circulating angiotensin II directly inhibits renin secretion independently of alterations in renal arterial blood pressure.
Administered intravenous infusions of angiotensin II at doses of 6.3 to 200 ng/kg·min in canine models.
Assessed renin secretion rates under both basal conditions and states of elevated renin release.
Monitored mean renal arterial blood pressure continuously during infusions.
Angiotensin II infusion consistently suppressed renin secretion under both basal conditions and elevated secretion states.
Renin inhibition occurred independently of changes in mean renal arterial blood pressure, supporting a direct negative feedback effect.

Structured PICO

Does intravenous infusion of angiotensin II inhibit renin secretion in dogs?

P

Population

dogs under conditions of basal or elevated renin secretion

I

Intervention

Intravenous infusion of angiotensin II (6.3-200 ng/kg min)

O

Outcome

renin secretionsurrogate

Angiotensin II exerts a negative feedback effect on renin secretion that is independent of renal arterial blood pressure.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Angiotensin II directly suppresses renin in canine models independent of pressure; hypothesis-generating for human RAAS regulation.

Abstract

Intravenous infusion of angiotensin II (6.3-200 ng/kg min) inhibited renin secretion in dogs under conditions of basal or elevated renin secretion. This inhibition was independent of changes in mean renal arterial blood pressure. We propose a negative feedback effect of circulating angiotensin on renin secretion.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Vander et al. (1965) studied this question.

synapsesocial.com/papers/6a6f918678a11c550e094ae3 https://doi.org/10.3181/00379727-120-30547

View at Publisher

Ask AI

Bookmark

Share

Inhibition of Renin Secretion by Angiotensin .II.

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Inhibition of Renin Secretion by Angiotensin .II.

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading