Why the study?
Does the sympathetic nervous system (via renal nerves) contribute to sodium retention in Angiotensin II-induced hypertension?
Population
5 conscious chronically instrumented dogs subjected to unilateral renal denervation and surgical division of…
Comparison
Intravenous infusion of Angiotensin II for 5… vs Innervated kidneys and baseline control…
Design
Preclinical
Follow-up
5 days of infusion followed by a 5-day recovery period
Authors
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Challenges hypothesis of renal sympathetic-driven sodium retention in Ang II hypertension; leaves open translation to human disease.
Does the sympathetic nervous system (via renal nerves) contribute to sodium retention in Angiotensin II-induced hypertension?
In a canine model, renal nerves promote rather than impair sodium excretion during Angiotensin II-induced hypertension, challenging the hypothesis that increased renal sympathetic nerve activity contributes to this form of hypertension.
Lohmeier et al. (1998) studied this question.
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