What question did this study set out to answer?

This research aims to understand how baroreflexes influence sodium retention in the context of angiotensin-induced hypertension.

October 1, 2000AJP Regulatory Integrative and Comparative Physiology

Baroreflexes prevent neurally induced sodium retention in angiotensin hypertension

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Population

Conscious dogs subjected to unilateral renal denervation and surgical division of the urinary bladder into…

Comparison

ANG II infusion for 5 days at a rate of 5… vs Control measurements prior to ANG II infusion…

Design

Preclinical

Follow-up

5 days

Authors

TLThomas E. LohmeierJackson Memorial Hospital JLJustin R. LohmeierUniversity of Mississippi Medical Center AHAtif HaqueUniversity of Mississippi Medical Center

Discussion

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Implication

Baroreflexes may limit neural sodium retention in experimental ANG II hypertension; extends mechanistic insights but leaves open human translation.

Key Points

This research aims to understand how baroreflexes influence sodium retention in the context of angiotensin-induced hypertension.
Conducted experiments in conscious dogs with unilateral renal denervation and bladder division for urine collection.
Dogs underwent measurements in intact state, after cardiopulmonary denervation, and after additional sinoaortic denervation.
ANG II was infused for 5 days at a rate of 5 ng.kg(-1).min(-1) to observe changes in sodium excretion.
Control sodium excretion ratio from Den to Inn kidneys was 1.04 +/- 0.04 before ANG II infusion.
Throughout ANG II infusion, sodium excretion decreased significantly in Den kidneys, showing chronic renal sympathoinhibition (day 5 Den/Inn sodium = 0.51 +/- 0.05).
Cardiopulmonary denervation abolished the decrease in sodium excretion in response to ANG II, indicating baroreflex involvement.

Structured PICO

Population

Conscious dogs subjected to unilateral renal denervation and surgical division of the urinary bladder into hemibladders

Intervention

ANG II infusion for 5 days at a rate of 5 ng.kg(-1).min(-1) evaluated in three states: 1) intact, 2) after cardiopulmonary denervation (CPD), and 3) after CPD plus complete sinoaortic denervation (CPD + SAD)

Comparator

Control measurements prior to ANG II infusion, and intra-subject comparison between denervated (Den) and innervated (Inn) kidneys

Outcome

Mean arterial pressure (MAP) and the ratio for urinary sodium excretion from Den and Inn kidneys (Den/Inn)surrogate

Cardiac and/or arterial baroreflexes chronically inhibit renal sympathetic nerve activity during ANG II hypertension, preventing neurally induced sodium retention.

Cite This Study

Lohmeier et al. (2000) studied this question.

synapsesocial.com/papers/6a756afa9fe5b048e4e71569 https://doi.org/10.1152/ajpregu.2000.279.4.r1437

Topics

Hypertension management

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Implication

Baroreflexes may limit neural sodium retention in experimental ANG II hypertension; extends mechanistic insights but leaves open human translation.

Baroreflexes prevent neurally induced sodium retention in angiotensin hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Baroreflexes prevent neurally induced sodium retention in angiotensin hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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