Key result
Bilateral renal denervation in dogs did not abolish the sustained reductions in mean arterial pressure (approximately 13 mm Hg) during prolonged activation of the carotid baroreflex.
Authors
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Renal innervation may mediate sustained baroreflex BP lowering in dogs; leaves open translation to human hypertension therapy.
Lohmeier et al. (2006) studied this question. Bilateral renal denervation vs. Intact renal innervation (before denervation) was evaluated on Mean arterial pressure. Bilateral renal denervation in dogs did not abolish the sustained reductions in mean arterial pressure (approximately 13 mm Hg) during prolonged activation of the carotid baroreflex.
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