Key result
Computer simulations demonstrated that baroreflex-mediated suppression of renal sympathetic nerve activity chronically increases renal excretory function via hormonal and haemodynamic mechanisms.
Population
Mathematical model of human physiology (QHP2008)
Comparison
Simulated baroreflex activation vs Simulated conditions without baroreflex…
Design
Other
Authors
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Hypothesis-generating for baroreflex effects on renal function; leaves open translation to clinical hypertension management.
Computer simulations demonstrate that redundant natriuretic mechanisms mediate sustained blood pressure reductions during baroreflex activation even when renal sympathetic suppression is prevented.
Iliescu et al. (2009) studied Blood pressure control. Baroreflex activation was evaluated on Physiological mechanisms mediating sustained reductions in arterial pressure. Computer simulations demonstrated that baroreflex-mediated suppression of renal sympathetic nerve activity chronically increases renal excretory function via hormonal and haemodynamic mechanisms.
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