What question did this study set out to answer?

To compare the cardiovascular, renal, and neurohormonal effects of systemic baroreflex activation versus bilateral surgical renal denervation in obesity-induced hypertension.

December 20, 2011Hypertension

Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension

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Why the study?

Does chronic baroreflex activation or renal denervation improve cardiovascular and renal parameters in dogs with obesity-induced hypertension?

Population

Dogs with sympathetically mediated, obesity-induced hypertension (induced by 4 weeks of high-fat diet)

Comparison

Chronic baroreflex activation or bilateral… vs Control measurements

Design

Preclinical

Follow-up

7 days (for chronic baroreflex activation)

Authors

TLThomas E. LohmeierJackson Memorial Hospital RIRadu IliescuGrigore T. Popa University of Medicine and Pharmacy BLBoshen LiuUniversity of Science and Technology Beijing

Discussion

Member takes

Implication

Baroreflex activation may confer added autonomic and renal benefits in obesity hypertension; leaves open translation to human therapy.

Key Points

To compare the cardiovascular, renal, and neurohormonal effects of systemic baroreflex activation versus bilateral surgical renal denervation in obesity-induced hypertension.
Fed dogs a high-fat diet until body weight increased ≈50%, elevating mean arterial pressure from 100±2 to 117±3 mm Hg and heart rate from 86±3 to 130±4 bpm alongside marked sodium retention.
Evaluated physiological and renal hemodynamic responses following 7 days of chronic electrical baroreflex activation versus bilateral surgical renal denervation.
Both 7-day baroreflex activation and surgical renal denervation reduced plasma renin activity and abolished obesity-induced hypertension.
Baroreflex activation uniquely suppressed systemic sympathetic activity, abolished tachycardia, reduced glomerular hyperfiltration, and elevated fractional sodium excretion.
Surgical renal denervation caused glomerular filtration rate to increase further rather than attenuating hyperfiltration.

Structured PICO

Does chronic baroreflex activation or renal denervation improve cardiovascular and renal parameters in dogs with obesity-induced hypertension?

Population

Dogs with sympathetically mediated, obesity-induced hypertension (induced by 4 weeks of high-fat diet)

Intervention

Chronic baroreflex activation (7 days) or bilateral surgical renal denervation

Comparator

Control measurements (baseline before intervention)

Outcome

Cardiovascular, renal, and neurohormonal responses (including mean arterial pressure, heart rate, glomerular filtration rate, fractional sodium excretion, and plasma renin activity)surrogate

Suppression of global sympathetic activity by baroreflex activation may have beneficial effects in obesity beyond simply attenuating hypertension by improving autonomic control of cardiac function and diminishing glomerular hyperfiltration.

Cite This Study

Lohmeier et al. (2011) studied this question.

synapsesocial.com/papers/6a7012a635aa2c282ce15f45 https://doi.org/10.1161/hypertensionaha.111.185074

Topics

Hypertension management

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Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Systemic and Renal-Specific Sympathoinhibition in Obesity Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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