What question did this study set out to answer?

To determine whether circulating renin enhances adrenocortical sensitivity to ACTH and angiotensin II in stimulating aldosterone secretion.

April 1, 1967Endocrinology

Effect of Renin on Adrenocortical Sensitivity to ACTH and Angiotensin II in Dogs

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Why the study?

Does renin injection increase adrenocortical sensitivity to ACTH and angiotensin II in dogs?

Population

Dogs (hypophysectomized and nephrectomized after treatment)

Comparison

Dog renin injected for 5 days vs Noninjected control dogs

Design

Preclinical

Follow-up

5 days

Authors

WGWilliam F. GanongBank of America ABA. T. BoryczkaYale New Haven Hospital RSR. L. ShackelfordUniversity of California, San Francisco

Discussion

Member takes

Implication

Renin may heighten canine aldosterone responses to ACTH and angiotensin II; hypothesis-generating for human renin-angiotensin-aldosterone regulation.

Key Points

To determine whether circulating renin enhances adrenocortical sensitivity to ACTH and angiotensin II in stimulating aldosterone secretion.
Injected dogs with canine renin for 5 days, followed by surgical hypophysectomy and nephrectomy.
Measured aldosterone and 17-hydroxycorticoid secretory responses to ACTH and angiotensin II infusions relative to noninjected controls.
Monitored plasma electrolytes, urine output, and adrenocortical morphology.
Renin-treated dogs showed significantly greater increments in aldosterone output following ACTH and angiotensin II administration compared to controls.
Increments in 17-hydroxycorticoid secretion remained unchanged, and no adrenocortical hypertrophy or sodium diuresis was observed.
Plasma potassium fell significantly after renin treatment, while plasma sodium levels showed no significant change.

Structured PICO

Does renin injection increase adrenocortical sensitivity to ACTH and angiotensin II in dogs?

Population

Dogs (hypophysectomized and nephrectomized after treatment)

Intervention

Dog renin injected for 5 days

Comparator

Noninjected control dogs

Outcome

Increments in aldosterone output produced by ACTH and angiotensin IIsurrogate

Renin treatment in dogs increases the aldosterone-stimulating activity of ACTH and angiotensin II, supporting the hypothesis that circulating renin levels mediate this sensitivity during low sodium intake.

Cite This Study

Ganong et al. (1967) studied this question.

synapsesocial.com/papers/6a7708cee539f649abf6d702 https://doi.org/10.1210/endo-80-4-703

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Implication

Renin may heighten canine aldosterone responses to ACTH and angiotensin II; hypothesis-generating for human renin-angiotensin-aldosterone regulation.

Effect of Renin on Adrenocortical Sensitivity to ACTH and Angiotensin II in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Renin on Adrenocortical Sensitivity to ACTH and Angiotensin II in Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider