Why the study?
Does immunization with hog renin prevent aldosterone secretion in response to physiological stimuli in dogs?
Population
Dogs immunized with hog renin (with high circulating antirenin titers)
Design
Preclinical
Authors
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Renin immunization fails to block aldosterone response in dogs; leaves open whether antirenin strategies modulate aldosterone in humans.
Does immunization with hog renin prevent aldosterone secretion in response to physiological stimuli in dogs?
Dogs immunized with hog renin can still increase aldosterone secretion in response to stimuli, likely by secreting large amounts of renin that overcome circulating antirenin antibodies.
Ganong et al. (1965) studied this question.
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