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April 1, 1958CirculationOpen Access

Antibodies to Renin as Proof of the Pathogenesis of Sustained Renal Hypertension

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Why the study?

Do antibodies to renin produce an antihypertensive effect in dogs with chronic renal hypertension?

Population

Dogs with chronic renal hypertension

Design

Preclinical

Authors

GWG. E. WakerlinU.S. National Science Foundation

Discussion

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Implication

Antirenin antibodies lower BP in this canine model; hypothesis-generating for renin as a therapeutic target in hypertension.

Structured PICO

Do antibodies to renin produce an antihypertensive effect in dogs with chronic renal hypertension?

P
Population
Dogs with chronic renal hypertension
I
Intervention
Intramuscular injections of hog renin or passive transfer of high titer homologous antiserum to hog renin
O
Outcome
Antihypertensive effect correlated with antirenin titerssurrogate

Antibodies to renin produce an antihypertensive effect in dogs, suggesting a pathogenetic role for renin in experimental renal hypertension.

Cite This Study

G. E. Wakerlin (1958) studied this question.

synapsesocial.com/papers/6a7cc327273accedbda8b39fhttps://doi.org/10.1161/01.cir.17.4.653

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin and Antirenin in Treatment of Long Term Experimental Renal Hypertension in the Dog.1955 · 20 citations
  2. 2Reductions in Blood Pressures of Renal Hypertensive Dogs by Hog Renin.1941 · 18 citations
  3. 3Chronic Pressor Effect of Kidney Extracts Containing Renin in Experimental Hypertensions1954 · 5 citations
  4. 4Pathogenesis of Spontaneous and Pyelonephritic Hypertension in the Dog1957 · 37 citations