Why the study?
Does daily intramuscular injection of renin produce a chronic pressor effect in renal hypertensive dogs compared to normotensive dogs?
Population
Renal hypertensive dogs and normotensive dogs
Comparison
Daily intramuscular injections of dog renin or… vs Normotensive dogs (for responsiveness comparison)
Design
Preclinical
Follow-up
months
Authors
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Should not change human practice; leaves open renin’s chronic role in clinical renal hypertension.
Does daily intramuscular injection of renin produce a chronic pressor effect in renal hypertensive dogs compared to normotensive dogs?
Intramuscular injections of dog renin produce a sustained chronic pressor effect in renal hypertensive dogs, dependent on the absence of antirenin.
Wakerlin et al. (1954) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: