Why the study?
Does daily intramuscular injection of hog renin reduce blood pressure in renal ischemic hypertensive dogs?
Population
Renal ischemic hypertensive dogs
Comparison
Daily intramuscular injections of hog renin for… vs Heat inactivated hog renin and active dog renin
Design
Preclinical
Follow-up
4 months
Authors
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Heterologous renin immunogenicity may lower BP in canine renal hypertension; leaves open any clinical translation or mechanism in humans.
Does daily intramuscular injection of hog renin reduce blood pressure in renal ischemic hypertensive dogs?
Heterologous hog renin injections reduce blood pressure in renal hypertensive dogs, likely via an immune response.
Wakerlin et al. (1941) studied this question.
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