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Does plasma from dogs immunized with hog renin inhibit the aldosterone-stimulating and pressor activities of renin in nephrectomized hypophysectomized assay dogs?
Does plasma from dogs immunized with hog renin inhibit the aldosterone-stimulating and pressor activities of renin in nephrectomized hypophysectomized assay dogs?
Plasma from dogs immunized with hog renin contains factors (likely antibodies) that inhibit the pressor and steroidogenic activities of both hog and dog renin.
Immunized plasma inhibits renin bioactivity in canine assays; hypothesis-generating for antibody-based renin blockade in experimental hypertension.
SummaryThe aldosterone-stimulating and 17-hydroxycorticoid-stimulating activity, as well as the pressor activity, of both hog and dog renin were inhibited when prior to injection into nephrectomized hypophysectomized assay dogs, the renin preparations were incubated with the plasma of dogs immunized with hog renin. Incubation with normal dog plasma had no effect on their activity.
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Ganong et al. (1963) studied this question.
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