Why the study?
Does administration of hog renin or homologous antirenin reduce blood pressure in dogs with long-term experimental renal hypertension?
Population
Dogs with experimental renal hypertension of 4 or more years duration
Design
Preclinical
Authors
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Supports renin as sustained driver in chronic experimental hypertension; leaves open translation to human therapy.
Does administration of hog renin or homologous antirenin reduce blood pressure in dogs with long-term experimental renal hypertension?
Renin remains the principal pathogenetic factor in experimental renal hypertension even after many years of duration in dogs.
Kremen et al. (1955) studied this question.
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