Why the study?
Does administration of antirenin to human renin reduce blood pressure in monkeys with experimental renal hypertension?
Population
Monkeys with experimental renal hypertension induced by unilateral 3:1 renal artery constriction
Comparison
Crude human renin or passive administration of… vs Semipurified hog renin, dog serum containing…
Design
Preclinical
Authors
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Antirenin to human renin treats primate experimental renal hypertension; leaves open translation to human therapy.
Does administration of antirenin to human renin reduce blood pressure in monkeys with experimental renal hypertension?
Renin plays a key role in the pathogenesis of primate experimental renal hypertension, which can be successfully treated with antirenin to human renin.
M Frank (1963) studied this question.
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