Why the study?
Do renin-angiotensin system antagonists reduce blood pressure in a cynomolgus monkey model of high-renin hypertension?
Population
Cynomolgus monkeys
Comparison
Renal artery stenosis followed by administration… vs Baseline/control state
Design
Preclinical
Follow-up
6 months
Authors
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Supports cynomolgus 2K1C model for RAS antagonist testing in high-renin states; leaves open human translation.
Do renin-angiotensin system antagonists reduce blood pressure in a cynomolgus monkey model of high-renin hypertension?
A 2-kidney, 1-clip model of renal artery stenosis in cynomolgus monkeys successfully induces high-renin hypertension that is responsive to renin-angiotensin system antagonists.
Panek et al. (1991) studied this question.
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