January 1, 1984Clinical and Experimental Hypertension
Antisera to Human Renin Normalize Renin-Dependent Hypertension in the Monkey: Therapeutic Implications
Why the study?
Does intravenous infusion of polyclonal antisera to human renin reduce mean arterial pressure in monkey models of renin-dependent hypertension?
Population
Monkeys, including salt-repleted, salt-depleted, and conscious uninephrectomized models with suprarenal…
Design
Preclinical
Follow-up
10 hours
Authors
Discussion
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Implication
Supports renin inhibition as antihypertensive strategy; hypothesis-generating and requires human trials before any clinical consideration.
Structured PICO
Does intravenous infusion of polyclonal antisera to human renin reduce mean arterial pressure in monkey models of renin-dependent hypertension?
P
Population
Monkeys (M. fascicularis), including salt-repleted, salt-depleted, and conscious uninephrectomized models with suprarenal aortic cuff inflation.
I
Intervention
Intravenous infusion of 2 ml of polyclonal antisera raised against pure human renin.
O
Outcome
Mean arterial pressuresurrogate
Intravenous administration of antisera to human renin effectively normalizes blood pressure in primate models of renin-dependent hypertension, providing early evidence for renin inhibition as a therapeutic strategy.
Cite This Study
Slater et al. (1984) studied this question.