Why the study?
Does a specific renin-inhibitory peptide reduce mean arterial pressure in sodium-depleted and renin-dependent hypertensive monkey models?
Population
Monkeys including sodium-replete, sodium-depleted, and uninephrectomized models with suprarenal aortic cuff…
Comparison
Angiotensin substrate analog… vs Teprotide 1 mg/kg
Design
Preclinical
Authors
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Supports BP reduction by renin-inhibitory peptide in monkey models; leaves open translation to human hypertension.
Does a specific renin-inhibitory peptide reduce mean arterial pressure in sodium-depleted and renin-dependent hypertensive monkey models?
A specific angiotensinogen analog effectively inhibits renin in vivo, reducing blood pressure in sodium-depleted and renin-dependent hypertensive monkey models.
Burton et al. (1980) studied this question.
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