Why the study?
Do renin inhibitors lower blood pressure in preclinical models?
Population
Primates and normotensive marmosets
Comparison
Renin inhibitors vs Angiotensin-converting enzyme inhibitors (ACEI)
Design
Review
Authors
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Supports BP-lowering potential of renin inhibitors in primates; leaves open clinical development pending improved oral bioavailability.
Do renin inhibitors lower blood pressure in preclinical models?
Renin inhibitors demonstrate potent blood pressure-lowering effects in primate models comparable to ACE inhibitors, though oral bioavailability remains a challenge.
Corvol et al. (1989) studied this question.
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