What question did this study set out to answer?

To investigate changes in plasma immunoreactive renin concentrations during renin inhibition in conscious sodium-depleted marmosets using a novel enzyme-linked immunosorbent assay.

May 1, 1985Hypertension

Increased plasma renin during renin inhibition. Studies with a novel immunoassay.

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Why the study?

Does renin inhibition with CGP 29 287 increase plasma immunoreactive renin in sodium-depleted marmosets?

Population

Conscious marmosets after mild or severe sodium depletion

Comparison

Renin inhibitor CGP 29 287, enalaprilat, or… vs Pretreatment values

Design

Preclinical

Follow-up

up to 120 minutes

Authors

KHK. G. HofbauerNovartis (Switzerland)JWJ.M. WoodNovartis (Switzerland)NGN GulatiIcahn School of Medicine at Mount Sinai

Discussion

Member takes

Implication

Suggests compensatory immunoreactive renin rise during inhibition in primates; leaves open human translation and therapeutic relevance.

Key Points

To investigate changes in plasma immunoreactive renin concentrations during renin inhibition in conscious sodium-depleted marmosets using a novel enzyme-linked immunosorbent assay.
Administered the statine-containing renin inhibitor CGP 29 287 (0.1 and 1.0 mg/kg i.v.), enalaprilat (2 mg/kg i.v.), or hydralazine (0.2 mg/kg i.v.) to conscious marmosets under mild or severe sodium depletion.
Quantified enzymatic plasma renin activity in parallel with total immunoreactive renin concentration via a multirange enzyme-linked immunosorbent assay.
CGP 29 287 at 0.1 mg/kg and 1.0 mg/kg i.v. reduced mean arterial pressure and completely inhibited plasma renin activity for up to 30 and 120 minutes, respectively, alongside sustained elevations in immunoreactive renin.
In severely sodium-depleted marmosets, CGP 29 287 (1.0 mg/kg i.v.) increased plasma immunoreactive renin levels to 257% of baseline, while enalaprilat increased levels to 210%, and hydralazine caused no significant increase despite similar hypotension.

Structured PICO

Does renin inhibition with CGP 29 287 increase plasma immunoreactive renin in sodium-depleted marmosets?

Population

Conscious marmosets after mild or severe sodium depletion

Intervention

Renin inhibitor CGP 29 287 (0.1 mg/kg or 1.0 mg/kg i.v.), enalaprilat (2 mg/kg i.v.), or hydralazine (0.2 mg/kg i.v.)

Comparator

Pretreatment values

Outcome

Changes in plasma immunoreactive renin concentration and plasma renin activitysurrogate

Renin inhibition with CGP 29 287 completely inhibits plasma renin activity while causing a sustained increase in plasma immunoreactive renin concentration in a primate model.

Cite This Study

Hofbauer et al. (1985) studied this question.

synapsesocial.com/papers/6a77ecda1400807f0f1edb69 https://doi.org/10.1161/01.hyp.7.3_pt_2.i61

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May 1, 1985Hypertension

Increased plasma renin during renin inhibition. Studies with a novel immunoassay.

View Full Paper

Ask AI

Bookmark

Why the study?

Does renin inhibition with CGP 29 287 increase plasma immunoreactive renin in sodium-depleted marmosets?

Population

Conscious marmosets after mild or severe sodium depletion

Comparison

Renin inhibitor CGP 29 287, enalaprilat, or… vs Pretreatment values

Design

Preclinical

Follow-up

up to 120 minutes

Authors

KHK. G. HofbauerNovartis (Switzerland)JWJ.M. WoodNovartis (Switzerland)NGN GulatiIcahn School of Medicine at Mount Sinai

Discussion

Member takes

Implication

Suggests compensatory immunoreactive renin rise during inhibition in primates; leaves open human translation and therapeutic relevance.

Key Points

To investigate changes in plasma immunoreactive renin concentrations during renin inhibition in conscious sodium-depleted marmosets using a novel enzyme-linked immunosorbent assay.
Administered the statine-containing renin inhibitor CGP 29 287 (0.1 and 1.0 mg/kg i.v.), enalaprilat (2 mg/kg i.v.), or hydralazine (0.2 mg/kg i.v.) to conscious marmosets under mild or severe sodium depletion.
Quantified enzymatic plasma renin activity in parallel with total immunoreactive renin concentration via a multirange enzyme-linked immunosorbent assay.
CGP 29 287 at 0.1 mg/kg and 1.0 mg/kg i.v. reduced mean arterial pressure and completely inhibited plasma renin activity for up to 30 and 120 minutes, respectively, alongside sustained elevations in immunoreactive renin.
In severely sodium-depleted marmosets, CGP 29 287 (1.0 mg/kg i.v.) increased plasma immunoreactive renin levels to 257% of baseline, while enalaprilat increased levels to 210%, and hydralazine caused no significant increase despite similar hypotension.

Structured PICO

Does renin inhibition with CGP 29 287 increase plasma immunoreactive renin in sodium-depleted marmosets?

Population

Conscious marmosets after mild or severe sodium depletion

Intervention

Renin inhibitor CGP 29 287 (0.1 mg/kg or 1.0 mg/kg i.v.), enalaprilat (2 mg/kg i.v.), or hydralazine (0.2 mg/kg i.v.)

Comparator

Pretreatment values

Outcome

Changes in plasma immunoreactive renin concentration and plasma renin activitysurrogate

Renin inhibition with CGP 29 287 completely inhibits plasma renin activity while causing a sustained increase in plasma immunoreactive renin concentration in a primate model.

Cite This Study

Hofbauer et al. (1985) studied this question.

synapsesocial.com/papers/6a77ecda1400807f0f1edb69 https://doi.org/10.1161/01.hyp.7.3_pt_2.i61

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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