Why the study?
Does the use of angiotensinase inhibitors in PRA assays cause overestimation of renin inhibition by displacing protein-bound renin inhibitors in hypertensive subjects?
Population
Subjects with hypertension and in vitro EDTA plasma samples
Comparison
Renin inhibitor Ro 42-5892 and in vitro testing… vs PRA assays performed without angiotensinase…
Design
Other
Follow-up
6-8 hours
Authors
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PRA assays using angiotensinase inhibitors may artifactually overestimate renin inhibitor duration; leaves open need for assay modification in clinical monitoring.
Does the use of angiotensinase inhibitors in PRA assays cause overestimation of renin inhibition by displacing protein-bound renin inhibitors in hypertensive subjects?
The apparent nonparallel effects of renin inhibitors on PRA and angiotensins are an in vitro artifact caused by angiotensinase inhibitors displacing protein-bound renin inhibitors during the assay.
Derkx et al. (1991) studied this question.
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