Why the study?
Does the renin inhibitor Ro 42-5892 suppress plasma angiotensin levels in healthy volunteers?
Population
38 healthy volunteers (14 in preliminary IV study, 24 in oral study)
Comparison
Ro 42-5892 via 10-min IV infusion or oral… vs Placebo (in the oral study)
Design
RCT, randomized fashion, single-blind
Follow-up
8 hours
Authors
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Ro 42-5892 yields only transient angiotensin suppression; confirms compensatory renin elevation limits duration of renin inhibition.
Does the renin inhibitor Ro 42-5892 suppress plasma angiotensin levels in healthy volunteers?
Renin inhibition with Ro 42-5892 causes a transient decrease in angiotensin levels that is overcome by a compensatory rise in renin secretion.
Camenzind et al. (1991) studied this question.
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