Why the study?
Does the renin inhibitor RO 42-5892 reduce blood pressure and angiotensin II levels in men with uncomplicated essential hypertension?
Population
9 men with uncomplicated essential hypertension who had a normal sodium intake
Comparison
RO 42-5892 given as two single intravenous doses… vs Placebo (active treatment was preceded by placebo)
Design
Cohort
Follow-up
24 hours
Authors
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May support oral renin inhibition for BP lowering in hypertension; leaves open confirmation in randomized trials and independence from angiotensin II effects.
Does the renin inhibitor RO 42-5892 reduce blood pressure and angiotensin II levels in men with uncomplicated essential hypertension?
The renin inhibitor RO 42-5892 is orally active and provides prolonged blood pressure reduction in patients with essential hypertension, independent of circulating angiotensin II suppression.
Meiracker et al. (1990) studied this question.
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