Why the study?
Does A-64662 reduce plasma renin activity and blood pressure in patients with essential hypertension?
Population
11 patients with essential hypertension, maintained on a constant 100 mEq Na diet.
Comparison
A-64662 administered as a single intravenous… vs Vehicle.
Design
Cohort
Follow-up
Acute (responses measured up to 110 min after injection)
Authors
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PRA suppression by A-64662 may not lower BP in essential hypertension; leaves open renin inhibition efficacy.
Does A-64662 reduce plasma renin activity and blood pressure in patients with essential hypertension?
A-64662 effectively inhibits plasma renin activity but has a dissociated, minimal, and transient effect on blood pressure in patients with essential hypertension.
Bursztyn et al. (1990) studied this question.
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