Why the study?
Does the renin inhibitor A-64662 reduce mean arterial pressure in monkeys with varying baseline plasma renin activity?
Population
Monkeys and rats. Specifically detailed: 30 normal and 30 salt-depleted anesthetized monkeys, and a second…
Comparison
A-64662 administered as an i.v. bolus at doses… vs Vehicle
Design
Preclinical
Authors
Loading...
May enhance BP lowering in high-renin states; leaves open translation of renin inhibitors to clinical hypertension.
Does the renin inhibitor A-64662 reduce mean arterial pressure in monkeys with varying baseline plasma renin activity?
The hypotensive efficacy of the renin inhibitor A-64662 is dependent on baseline plasma renin activity, with greater sensitivity observed in salt-depleted states.
Kleinert et al. (1988) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: