Key result
Renin inhibitor SR 43845 reduces blood pressure by ~22 mmHg, comparable to captopril in macaques.
Why the study?
Does the renin inhibitor SR 43845 reduce blood pressure and alter plasma active renin compared to captopril in conscious sodium-replete macaca?
Population
Conscious, chronically instrumented, sodium-replete macaca (cynomolgus monkeys)
Comparison
Renin inhibitor SR 43845 vs ACE inhibitor captopril
Design
Preclinical
Follow-up
5 hours post-infusion
Authors
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Supports renin inhibition as BP-lowering alternative to ACE inhibition in primates; leaves open translation to human hypertension.
Does the renin inhibitor SR 43845 reduce blood pressure and alter plasma active renin compared to captopril in conscious sodium-replete macaca?
In a primate model, the renin inhibitor SR 43845 and the ACE inhibitor captopril produced similar maximal hypotensive effects, though renin inhibition was slightly more efficient.
Lacour et al. (1989) studied Conscious, chronically instrumented, sodium-replete macaca (cynomolgus monkeys). SR 43845 vs. Captopril was evaluated on Blood pressure and plasma active renin. Perfusion of the renin inhibitor SR 43845 elicited a dose-related decrease in blood pressure (maximal reduction 22 ± 2 mmHg) comparable to the ACE inhibitor captopril in sodium-replete macaca.
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