Why the study?
Does H.261 reduce angiotensin II and mean arterial pressure compared to captopril in anaesthetized baboons?
Population
6 anaesthetized baboons
Comparison
H.261 intravenous infusion at 0.1 mumol/kg/h for… vs Captopril intravenous infusion at 25 mumol/kg/h…
Design
Preclinical
Follow-up
Acute (minutes to hours)
Authors
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H.261 supports preclinical testing of renin inhibition; leaves open translation to human hypertension trials.
Does H.261 reduce angiotensin II and mean arterial pressure compared to captopril in anaesthetized baboons?
The novel renin inhibitor H.261 acutely lowers blood pressure and angiotensin II levels in baboons to a similar extent as captopril.
Szelke et al. (1985) studied this question.
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