In Vitro and In Vivo Inhibition of Human and Primate Renin by a New Potent Renin Inhibitor

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Why the study?

Does the novel renin inhibitor SR 42128 reduce blood pressure and inhibit plasma renin activity in sodium-depleted monkeys?

Population

In vitro human and primate plasma renin, and in vivo sodium-depleted conscious monkeys

Design

Preclinical

Follow-up

3 hours

Authors

Discussion

Supports preclinical renin inhibitor validation; leaves open translation to human hypertension trials.

Does the novel renin inhibitor SR 42128 reduce blood pressure and inhibit plasma renin activity in sodium-depleted monkeys?

Population

In vitro human and primate plasma renin, and in vivo sodium-depleted conscious monkeys

Intervention

SR 42128 (Iva-Phe-Nle-Sta-Ala-Sta-OH) and its arginine salt SR 42128A (single dose of 3 or 10 mg/kg in monkeys)

Outcome

Inhibition of plasma renin activity (PRA) and blood pressure decreasesurrogate

SR 42128 is a potent, long-acting renin inhibitor that effectively lowers blood pressure and inhibits plasma renin activity in primate models.

Clavière et al. (1985) studied this question.

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