Renin inhibitors containing a pyridyl amino diol derived C-terminus

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Population

In vitro human renin and in vivo anesthetized, sodium-depleted rhesus monkeys

Design

Preclinical

Follow-up

90 min

Authors

Discussion

Supports development of nonpeptide renin inhibitors; leaves open translation from primate models to human hypertension.

Population

In vitro human renin and in vivo anesthetized, sodium-depleted rhesus monkeys

Intervention

Nonpeptide renin inhibitors containing a pyridyl amino diol derived C-terminus (specifically Compound 38 / S 2864, 2 mg/kg intraduodenal)

Outcome

Inhibition of renin in vitro and reduction in mean arterial blood pressure (MAP) in vivosurrogate

Compound 38 is a potent nonpeptide renin inhibitor that significantly reduces mean arterial blood pressure in a primate model.

Heitsch et al. (1993) studied this question.

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