Population
Human plasma renin (in vitro) and male Sprague-Dawley rats (in vivo)
Comparison
Low molecular weight renin inhibitors (e.g… vs Original lead structure (Boc-Phe-His-Leu-psi[CHCH…
Design
Preclinical
Authors
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Advances low-MW renin inhibitor leads in animals; leaves open human efficacy, safety, and absorption trials.
A new class of low molecular weight renin inhibitors demonstrates high potency, specificity, and encouraging evidence of intestinal absorption in preclinical models.
SUEIRAS‐DIAZ et al. (1997) studied this question.
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