Population
In vitro assays and salt-depleted normotensive cynomolgus monkey model
Design
Preclinical
Authors
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Hypothesis-generating for novel renin inhibitors; leaves open translation to human hypertension therapy.
Compound 42 is a novel renin inhibitor demonstrating high in vitro potency, specificity, and significant in vivo hypotensive efficacy in a primate model.
Doherty et al. (1991) studied this question.