December 1, 1983Journal of Hypertension

New Inhibitors of Human Renin Tested in vitro and in vivo in the Anaesthetized Baboon

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Population

In vitro human, baboon, dog, and rat plasma renin; in vivo n=4 anaesthetized salt-deplete baboons

Design

Preclinical

Authors

MTM. TreeMurdoch University BAButrus AtrashCancer Research UK BDBrian T. DonovanLoyola University Chicago

Discussion

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Implication

Supports further preclinical optimization of renin inhibitors; leaves open their role in human hypertension therapy.

Structured PICO

Population

In vitro human, baboon, dog, and rat plasma renin; in vivo n=4 anaesthetized salt-deplete baboons (Papio hamadryas)

Intervention

Renin inhibitors H. 189 and H. 142 (intravenous infusion at 10 mg/kg/h in vivo)

Outcome

Inhibitory potency (IC50) in vitro; plasma renin activity and circulating concentrations of angiotensin I and II in vivosurrogate

Novel renin inhibitors H. 189 and H. 142 demonstrate potent in vitro inhibition of human renin and effectively reduce plasma renin activity and angiotensin levels in a baboon model.

Cite This Study

Tree et al. (1983) studied this question.

synapsesocial.com/papers/6a8587ae8018c50ef23da81e https://doi.org/10.1097/00004872-198312000-00013

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New Inhibitors of Human Renin Tested in vitro and in vivo in the Anaesthetized Baboon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

New Inhibitors of Human Renin Tested in vitro and in vivo in the Anaesthetized Baboon

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider