Population
Conscious sodium-deplete dogs; human renin and renin substrate analogues
Comparison
Peptide inhibitor of renin infusion, followed by… vs H.77 alone (before captopril addition)
Design
Preclinical
Authors
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Supports that captopril lowers BP primarily via angiotensin II reduction; hypothesis-generating in this animal model and requires clinical confirmation.
Peptide inhibitors of renin effectively lower angiotensin levels, and the lack of further blood pressure reduction with captopril suggests captopril acts primarily by reducing angiotensin II.
Leckie et al. (1983) studied this question.
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