October 25, 1999Canadian Journal of Physiology and Pharmacology

The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors

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Population

Ganglion-blocked, nephrectomized rats infused intravenously with recombinant human renin (2.4 microg x kg x…

Design

Preclinical

Authors

GBGordon T. BolgerGoethe University Frankfurt JVJean-Claude Vigeant FLFrancine LiardBoehringer Ingelheim (Egypt)

Discussion

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Implication

Validates the renin-infused rat model for preclinical oral renin inhibitor screening; leaves open any clinical translation.

Structured PICO

Population

Ganglion-blocked, nephrectomized rats infused intravenously with recombinant human renin (2.4 microg x kg(-1) x min(-1))

Intervention

Peptidomimetic P2-P3 butanediamide renin inhibitors (administered intravenously and orally), captopril, enalkiren, and losartan

Outcome

Inhibition of blood pressor response to infused human reninsurrogate

The human renin infused rat model is an effective in vivo system for evaluating the biological activity and oral bioavailability of human renin inhibitors.

Cite This Study

Bolger et al. (1999) studied this question.

synapsesocial.com/papers/6a77df587ecc675f86aeb038 https://doi.org/10.1139/y99-068

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The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The human renin infused rat: use as an in vivo model for the biological evaluation of human renin inhibitors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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