Key result
Hydroxy-ethylene dipeptide analogues lowered blood pressure and suppressed plasma renin and angiotensin II in renal hypertensive rats.
Why the study?
Do hydroxy-ethylene dipeptide analogues lower blood pressure and suppress renin/angiotensin II in renal hypertensive rats?
Population
Renal hypertensive rats
Design
Preclinical
Authors
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Hypothesis-generating for renin inhibition in hypertension; should not change clinical practice without human trials.
Do hydroxy-ethylene dipeptide analogues lower blood pressure and suppress renin/angiotensin II in renal hypertensive rats?
Hydroxy-ethylene dipeptide analogues are potent renin inhibitors that effectively lower blood pressure in experimental rat models of hypertension.
Beattie et al. (1989) studied Renal hypertension. Hydroxy-ethylene dipeptide analogues (Leu[CH(OH)-CH2]Leu and Leu[CH(OH)-CH2]Val) was evaluated on Blood pressure, plasma renin, and angiotensin II. Hydroxy-ethylene dipeptide analogues lowered blood pressure and suppressed plasma renin and angiotensin II in renal hypertensive rats.
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