April 1, 1997Hypertension
Dose Effects of Human Renin in Rats Transgenic for Human Angiotensinogen
Why the study?
Does human renin infusion increase blood pressure in rats transgenic for human angiotensinogen?
Population
Rats harboring the human angiotensinogen gene [TGR (hAOGEN)1623]
Comparison
Incremental doses of human renin infused via… vs Basal values / dose-response comparisons
Design
Preclinical
Follow-up
10 days
Authors
Discussion
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Member takes
Implication
Validates transgenic rat model for renin-dependent hypertension; leaves open clinical translation of renin inhibition.
Structured PICO
Does human renin infusion increase blood pressure in rats transgenic for human angiotensinogen?
P
Population
Rats harboring the human angiotensinogen gene [TGR (hAOGEN)1623]
I
Intervention
Incremental doses of human renin (1 to 500 ng/h) infused via minipumps for 10 days; human renin inhibitor Ro 42-5892 given by gavage
C
Comparator
Basal values / dose-response comparisons
O
Outcome
Blood pressure and heart rate measured continuously by telemetrysurrogate
The human angiotensinogen transgenic rat model demonstrates dose-dependent, high human renin hypertension associated with tachycardia, offering a new model for studying human renin-induced hypertension.
Cite This Study
Bohlender et al. (1997) studied this question.