Population
Double transgenic rats expressing human angiotensinogen and human renin (n=49)
Comparison
Lisinopril and remikiren vs Untreated double transgenic rats and…
Design
Preclinical
Follow-up
mean 55 days
Authors
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May accelerate preclinical testing of human renin inhibitors; leaves open clinical translation in hypertension.
The development of a double transgenic rat model expressing human renin and angiotensinogen provides a novel preclinical tool for studying renin-induced hypertension and testing human-specific renin inhibitors.
Bohlender et al. (1997) studied this question.
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