Population
Rats transgenic for human angiotensinogen (n=4)
Design
Preclinical
Follow-up
10 days
Authors
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Validates transgenic rat model of renin-dependent hypertension; leaves open translation to human therapies pending further studies.
Rats transgenic for human angiotensinogen infused with human renin develop severe hypertension, serving as a novel preclinical model for human renin-dependent hypertension.
Bohlender et al. (1996) studied this question.
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