February 1, 2001HypertensionOpen Access

Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II

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Why the study?

Does angiotensin II suppress human renin mRNA in transgenic mice with a 900-bp human renin promoter?

Structured PICO

Does angiotensin II suppress human renin mRNA in transgenic mice with a 900-bp human renin promoter?

Population

Transgenic mice containing the entire human renin gene with a 900-bp promoter

Intervention

Angiotensin II chronic infusion via osmotic minipump at low (200 ng/kg per minute) and high (1000 ng/kg per minute) doses, with or without hydralazine (15 mg/kg per day)

Comparator

Vehicle infusion

Outcome

Kidney renin mRNA levels (human and mouse) and blood pressuresurrogate

The first 900 bp of the human renin promoter lacks the necessary elements for appropriate angiotensin II-mediated suppression of human renin mRNA.

Discussion

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Implication

The 900-bp human renin promoter lacks angiotensin II-suppressive elements; leaves open mapping of required regulatory sequences in larger constructs.

Cite This Study

Keen et al. (2001) studied this question.

synapsesocial.com/papers/6a73610fd15b501a4dc1e447 https://doi.org/10.1161/01.hyp.37.2.403

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Implication

The 900-bp human renin promoter lacks angiotensin II-suppressive elements; leaves open mapping of required regulatory sequences in larger constructs.

Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II

Structured PICO

Discussion

Implication

Cite This Study

Paradoxical Regulation of Short Promoter Human Renin Transgene by Angiotensin II

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider